Systemic mastocytosis presenting as recurrent, refractory anaphylaxis

Fatal anaphylaxis in systemic mastocytosis.

A 42-year-old woman died after an episode of anaphylaxis associated with a raised serum histamine level. A diagnosis of systemic mastocytosis was established, with lymphadenopathy and hepatosplenomegaly, not associated with the usually pre-existing skin lesions of urticaria pigmentosa.

Recurrent syncope due to systemic mastocytosis.

A 59-year-old white woman, B. L., had been plagued by recurrent episodes of flushing, weakness, and dizziness that at times led to frank syncope. She had been well until December, 1974, when she experienced her first attack. This episode was characterized by the sudden onset of headache and fatigue followed by severe flushing (particularly of the face and neck), weakness of the legs, a feeling ...

Anaphylaxis in Mastocytosis*

M.C. Castells (ed.), Anaphylaxis and Hypersensitivity Reactions, DOI 10.1007/978-1-60327-951-2_16, © Springer Science+Business Media, LLC 2011 Abstract An increase in anaphylaxis has been reported in mastocytosis, with a predominance of males. Recurrent idiopathic anaphylaxis and either hymenoptera-venom or drug-induced anaphylaxis are the most frequent types of anaphylaxis, no correlation bein...

Anaphylaxis as a Manifestation of Systemic Mastocytosis: A Case Report and Review of Literature

Introduction: Anaphylaxis is defined as “a serious, life-threatening generalized or systemic hypersensitivity reaction” and “a serious allergic reaction that is rapid in onset and might cause death”. The determination of different mast cells (MC) mediators, such as serum and/or plasma histamine and tryptase, is proposed for the diagnosis of anaphylaxis. There are differences in the clinical pre...

Systemic mastocytosis as a risk factor for severe Hymenoptera sting-induced anaphylaxis.